克里L. 塔克,Ph值.D.
Associate Professor, Department of Biomedical 科学s, COM
位置
I come from the North Shore of Massachusetts, and I studied biochemistry at 哈佛学院, starting my research career purifying clathrin proteins from sheep brain at Harvard Medical School. I continued my studies as a graduate student at the Massachusetts Institute of Technology, 在剑桥, MA where I studied the role of DNA methylation in the development of the mouse, working in the lab of Rudolf Jaenisch. I then switched to developmental neuroscience as a postdoctoral fellow in the laboratory of Yves-Alain Barde at the Max Planck Institute of Neurobiology in Munich, 德国, and subsequently as a group leader at the University of Heidelberg, 德国, 从2003年到2013年. 在这个时候, I developed tools to visualize with fluorescent proteins the embryonic development of the central nervous system (CNS), using genetically-altered mice as a model. My laboratory has discovered that primary cilia, a special microtubule-based organelle found in every cell, control early events in CNS development, 包括形态发生, 边界的形成, 神经发生, 神经生长. 在德国工作, I developed many international collaborations exploring the role of primary cilia in the development of a variety of CNS structures, 包括前脑, 中脑, 脊髓. After my return to the USA as an Associate Professor at the University of New England, I am now moving into the analysis of postnatal phenotypes associated with loss of primary cilia in specific neuronal populations. We hope thereby to model some of the cognitive / neurodevelopmental defects seen in subsets of patients with so-called ciliopathies, multispectrum diseases associated with defects in proteins localizing to the primary cilium or the underlying basal body.
凭证
教育
研究
选定的出版物
Neuser F, Polack M, Annaheim C， 塔克K L, Korte M (2013) Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. 科学通报，8(6)，963 - 967. PMID: 23840491.
Nikolić M; Gardner H A R, 塔克K L (2013) Postnatal neuronal apoptosis in the cerebral cortex: Physiological and pathophysiological mechanisms. 神经科学学报，26 (4)，369-378.
Willaredt M A; Gorgas K; Gardner H A R; 塔克K L (2012) Mulitple essential roles for primary cilia in heart development. 西莉亚，1岁23岁. PMID: 23351706.
Scholl C; Weißmüller K; Pavlo Holenya P; Shaked-Rabi M; 塔克K L; Stefan Wölfl (2012) Distinct and overlapping gene regulatory networks in BMP- and HDAC-controlled cell fate determination in the embryonic forebrain. 中国生物医学工程学报，13,298. PMID: 22748179.
Tasouri E; 塔克K L (2011) Primary cilia and organogenesis: Is Sonic hedgehog the only sculptor? 中国生物医学工程学报，32 (1)，344 - 344.
Sanno H; Shen X; Kuru N; Bormuth I; Bobsin K; Gardner H A R; Komljenovic D; Tarabykin V; Erzurumlu R; 塔克K L (2010) Control of postnatal apoptosis in the neocortex by RhoA-subfamily GTPases determines neuronal density. 中华神经科学杂志，30(12)，422 - 431. PMID: 20335457.
Willaredt M A; Hasenpusch-Theil K; Gardner H A R; Kitanovic I; Hirschfeld-Warneken V C; Gojak C P; Gorgas K; Bradford C L; Spatz J; Wölfl S; Theil T; 塔克K L (2008) A crucial role for primary cilia in cortical morphogenesis. 中华神经科学杂志，28(8)，1287 -1290. PMID: 19036983.
Brachmann I; Jakubick V C; Shaked M; Unsicker K; 塔克K L (2007) A simple slice culture system for the imaging of nerve development in embryonic mouse. 中国生物医学工程学报，36(12)，344 - 344.
Wernig M; 贝宁格F; Schmandt T; Rade M; 塔克K L; Bussow H; Beck H; Brüstle O (2004) Functional integration of embryonic stem cell-derived neurons in vivo. 中华神经科学杂志，24(22)，5258-5268. PMID: 15175396.
Bibel M; Richter J; Schrenk K; 塔克K L; Staiger V; Korte M; Götz M; Barde Y-A (2004) Differentiation of mouse embryonic stem cells into a defined neuronal lineage. 中华神经科学杂志，7(9)，1003-1009.
贝宁格F.; Beck H; Wernig M; 塔克K L; Brüstle O; Scheffler B (2003) Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures. 中华神经科学杂志，23(18)，7075-7083. PMID: 12904468.
塔克K L; Meyer M; Barde Y-A (2001) Neurotrophins are required for nerve growth during development. 中华神经科学杂志，4(1)，29-37.
山下式T; 塔克K L; Barde Y-A (1999) Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. 神经学报，24(3)，585-593.